|
KMID : 1189420200330030027
|
|
Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2020 Volume.33 No. 3 p.27 ~ p.44
|
|
|
Evaluate efficacy of fermented soybean(Bio-Peptone)cream in pruritus : Randomized, double-blinded, placebo-controlled, parallel-group clinical experiment study
|
|
An Jae-Hyun
Jung Hyun-A
Kim Eun-Ju
Kim Ae-Jung
|
|
|
Abstract
|
|
|
Objectives : The authors conducted randomized, Double-blinded, and placebo-controlled parallel-group clinical experiment study to evaluate efficacy of fermented soybean(Bio-Peptone)cream in pruritus.
Methods : The research had been conducted for 4 months from the date of IRB approval(May 26 in 2017) to Sept 2017. The experiment started by randomly distributing 25 subjects with pruritus into experimental group and control group, respectively. The experimental group applied fermented soybean(Bio-Peptone)cream twice a day, in the morning and evening, for one week on itchy area. The effect of the product was evaluated by comparing the PSS(Patient subjective score), moisture level by measuring skin moisture content(Corneometer) and transepidermal water loss(Tewameter), and the Korean version of Skindex-29(index of quality of life improvement) before applying the cream, after applying the cream for one week and after stop applying the cream for one week. The control group conducted identical experiment with the experimental group, except the control group applied placebo instead of the fermented soybean(Bio-Peptone)cream.
Results : Pruritus, criterion of the first validation testing, indicates fermented soybean(Bio-Peptone)cream tend to reduce pruritus compare to placebo, although the result is not statistically noticeable. Significant difference in reduction of prutitus, the second validation test was not discovered in both groups. Corneometer and life quality tend to be improved with soy cream than placebo, but not statistically effective and both groups did not show any difference in terms of Tewameter measurement.
Conclusions : The result of clinical experiment didn’t prove that the fermented soybean(Bio-Peptone)cream is more effective in reducing pruritus than placebo, statistically. The clinical use of soybean product for pruritus requires further studies to be verified.
|
|
|
KEYWORD
|
|
|
Pruritus, Clinical experiment, Soy, Placebo, Randomize
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|